Remarkably, Apple has already addressed the fact that some users may be allergic to the material it uses.
According to Apple
A great deal of care and research go into choosing materials for all our devices.
In fact, every material that touches your skin has gone through extensive evaluation in accordance with our specification.
Thousands of material composition tests?
More than a thousand prototypes worn for trial studies?
Hundreds of toxicological assessments?
Further, Apple cautions about the methacrylates (which is found in the adhesive used in Band Aids).
But, people who are sensitive may develop sensitivities over time.
In that case, it is advisable to keep away from it.
A tight band can cause irritation while an overly loose band could cause rubbing.
source: www.techworm.net