Check with the developer to see to it Safari works with this version of Mac OS X.
You may have to reinstall the app.
Be sure to install any available updates for the tool and Mac OS X.
However, it now appears that Apple has pulled the iTunes 12.8.1 update.
Some users have found a workaround to fix Safari.
Note: These steps have not been tested by us.
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source: www.techworm.net